藥物交互作用
Carboplatin + Olaparib
嚴重程度: 嚴重
Carboplatin and Olaparib: major interaction.
最後更新
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摘要
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
用白話說明這項交互作用的意義
Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carboplatin belongs to Oncology; Olaparib belongs to Oncology.
為什麼會發生
Additive myelosuppression from a PARP inhibitor and a DNA-damaging platinum agent.
處置方式
Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carboplatin 的其他交互作用
Olaparib 的其他交互作用
常見問題
Can I take Carboplatin with Olaparib?
MediHelp rates the interaction as major. Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
How serious is the interaction between Carboplatin and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
