藥物交互作用
Carbamazepine + Olaparib
嚴重程度: 嚴重
Carbamazepine and Olaparib: major interaction.
最後更新
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摘要
Carbamazepine can substantially reduce olaparib exposure and may compromise anticancer efficacy.
用白話說明這項交互作用的意義
Carbamazepine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Olaparib belongs to Oncology.
為什麼會發生
Carbamazepine is a strong CYP3A4 inducer and increases the metabolism of olaparib, a CYP3A substrate.
處置方式
Avoid the combination and choose a non-inducing anticonvulsant such as levetiracetam. If unavoidable, consult the olaparib labeling for dosing and monitor response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbamazepine 的其他交互作用
Olaparib 的其他交互作用
常見問題
Can I take Carbamazepine with Olaparib?
MediHelp rates the interaction as major. Carbamazepine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine can substantially reduce olaparib exposure and may compromise anticancer efficacy.
How serious is the interaction between Carbamazepine and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing anticonvulsant such as levetiracetam. If unavoidable, consult the olaparib labeling for dosing and monitor response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
