藥物交互作用
Amiodarone + Olaparib
嚴重程度: 嚴重
Amiodarone and Olaparib: major interaction.
最後更新
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摘要
Amiodarone may increase olaparib exposure via CYP3A4 inhibition. This can increase anemia, nausea and other hematologic toxicity.
用白話說明這項交互作用的意義
Amiodarone and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Olaparib belongs to Oncology.
為什麼會發生
Amiodarone inhibits CYP3A4, decreasing olaparib metabolism.
處置方式
Avoid if possible; otherwise reduce olaparib to the labeled dose for moderate CYP3A inhibitors and monitor blood counts.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Olaparib 的其他交互作用
常見問題
Can I take Amiodarone with Olaparib?
MediHelp rates the interaction as major. Amiodarone and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may increase olaparib exposure via CYP3A4 inhibition. This can increase anemia, nausea and other hematologic toxicity.
How serious is the interaction between Amiodarone and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce olaparib to the labeled dose for moderate CYP3A inhibitors and monitor blood counts.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
