藥物交互作用
Carisoprodol + Clobazam
嚴重程度: 嚴重
Carisoprodol and Clobazam: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Benzodiazepines and carisoprodol together cause additive CNS depression, which may result in marked sedation, impaired coordination and respiratory depression. Carisoprodol can also modestly affect CYP2C19 activity, which may alter clobazam's active metabolite exposure.
用白話說明這項交互作用的意義
Carisoprodol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.
為什麼會發生
Additive CNS depression through GABA-A enhancement.
處置方式
Avoid the combination where possible, or use the lowest effective doses and monitor for sedation and respiratory depression. Counsel against alcohol and driving.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carisoprodol 的其他交互作用
Clobazam 的其他交互作用
常見問題
Can I take Carisoprodol with Clobazam?
MediHelp rates the interaction as major. Carisoprodol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines and carisoprodol together cause additive CNS depression, which may result in marked sedation, impaired coordination and respiratory depression. Carisoprodol can also modestly affect CYP2C19 activity, which may alter clobazam's active metabolite exposure.
How serious is the interaction between Carisoprodol and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective doses and monitor for sedation and respiratory depression. Counsel against alcohol and driving.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
