藥物交互作用
Chloral hydrate + Clobazam
嚴重程度: 嚴重
Chloral hydrate and Clobazam: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
用白話說明這項交互作用的意義
Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloral hydrate belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
為什麼會發生
Additive CNS depression through enhanced GABAergic inhibition.
處置方式
Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chloral hydrate 的其他交互作用
Clobazam 的其他交互作用
常見問題
Can I take Chloral hydrate with Clobazam?
MediHelp rates the interaction as major. Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
How serious is the interaction between Chloral hydrate and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
