藥物交互作用
Clobazam + Codeine
嚴重程度: 嚴重
Clobazam and Codeine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Clobazam may also weakly inhibit CYP2D6, which could reduce activation of codeine to morphine.
用白話說明這項交互作用的意義
Clobazam and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clobazam belongs to Central Nervous System; Codeine belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression, plus possible CYP2D6 inhibition by clobazam.
處置方式
Avoid or limit to patients with no alternative, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression, and consider naloxone.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Codeine 的其他交互作用
Clobazam 的其他交互作用
常見問題
Can I take Clobazam with Codeine?
MediHelp rates the interaction as major. Clobazam and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Clobazam may also weakly inhibit CYP2D6, which could reduce activation of codeine to morphine.
How serious is the interaction between Clobazam and Codeine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit to patients with no alternative, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression, and consider naloxone.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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