藥物交互作用
Caspofungin + Fosphenytoin
嚴重程度: 中度
Caspofungin and Fosphenytoin: moderate interaction.
最後更新
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摘要
Fosphenytoin is converted to phenytoin, an inducer that can lower caspofungin concentrations. The clinical impact is uncertain but could reduce antifungal efficacy in serious infection.
用白話說明這項交互作用的意義
Caspofungin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Fosphenytoin belongs to Central Nervous System.
為什麼會發生
Phenytoin induces clearance pathways of caspofungin, lowering exposure.
處置方式
Caspofungin labeling suggests considering a daily dose of 70 mg when given with inducers such as phenytoin in patients not responding adequately. Monitor clinical response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Caspofungin 的其他交互作用
Fosphenytoin 的其他交互作用
常見問題
Can I take Caspofungin with Fosphenytoin?
MediHelp rates the interaction as moderate. Caspofungin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin is converted to phenytoin, an inducer that can lower caspofungin concentrations. The clinical impact is uncertain but could reduce antifungal efficacy in serious infection.
How serious is the interaction between Caspofungin and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Caspofungin labeling suggests considering a daily dose of 70 mg when given with inducers such as phenytoin in patients not responding adequately. Monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
