藥物交互作用
Cefazolin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
嚴重程度: 中度
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
用白話說明這項交互作用的意義
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Antibiotic suppression of colonic bacteria needed to convert sodium picosulfate to its active metabolite.
處置方式
Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefazolin 的其他交互作用
常見問題
Can I take Cefazolin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
How serious is the interaction between Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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