藥物交互作用
Cefotaxime + Typhoid vaccine live
嚴重程度: 嚴重
Cefotaxime and Typhoid vaccine live: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi colonizing the gut. Cefotaxime is active against Salmonella and may reduce vaccine viability and the resulting immunity.
用白話說明這項交互作用的意義
Cefotaxime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Antibacterial activity inhibits the live attenuated Salmonella strain, reducing immunogenicity.
處置方式
Give live oral typhoid vaccine at least 3 days after the final cefotaxime dose, or vaccinate beforehand. Use the inactivated parenteral typhoid vaccine if timing cannot be separated.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cefotaxime 的其他交互作用
常見問題
Can I take Cefotaxime with Typhoid vaccine live?
MediHelp rates the interaction as major. Cefotaxime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi colonizing the gut. Cefotaxime is active against Salmonella and may reduce vaccine viability and the resulting immunity.
How serious is the interaction between Cefotaxime and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the final cefotaxime dose, or vaccinate beforehand. Use the inactivated parenteral typhoid vaccine if timing cannot be separated.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefotaxime page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
