藥物交互作用
Amikacin + Cefotaxime
嚴重程度: 中度
Amikacin and Cefotaxime: moderate interaction.
最後更新
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摘要
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
用白話說明這項交互作用的意義
Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefotaxime belongs to Anti Bacterial.
為什麼會發生
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
處置方式
Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefotaxime 的其他交互作用
Amikacin 的其他交互作用
常見問題
Can I take Amikacin with Cefotaxime?
MediHelp rates the interaction as moderate. Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
How serious is the interaction between Amikacin and Cefotaxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefotaxime page.
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