藥物交互作用
Ceftriaxone + Lactated ringer's
嚴重程度: 禁忌併用
Ceftriaxone and Lactated ringer's: contraindicated interaction.
最後更新 來源: US FDA label
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本頁的臨床內容僅提供英文版。
摘要
Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney crystal deposition have occurred in neonates. In neonates up to 28 days old, concurrent use is contraindicated, and in older patients the two must not be mixed or given simultaneously through the same line.
用白話說明這項交互作用的意義
Ceftriaxone and Lactated ringer's are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Physicochemical incompatibility: ceftriaxone binds calcium to form insoluble ceftriaxone-calcium salt that can precipitate in lines and in vivo.
處置方式
Do not give ceftriaxone to neonates (28 days or younger) who are receiving or expected to receive calcium-containing IV solutions.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
- Rocephin (ceftriaxone) Prescribing Information - Contraindications and Warnings: Interaction with Calcium-Containing Products — FDA Label
- Ceftriaxone Summary of Product Characteristics - Contraindications — EMA SmPC
Ceftriaxone 的其他交互作用
常見問題
Can I take Ceftriaxone with Lactated ringer's?
MediHelp rates the interaction as contraindicated. Ceftriaxone and Lactated ringer's are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney crystal deposition have occurred in neonates. In neonates up to 28 days old, concurrent use is contraindicated, and in older patients the two must not be mixed or given simultaneously through the same line.
How serious is the interaction between Ceftriaxone and Lactated ringer's?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ceftriaxone to neonates (28 days or younger) who are receiving or expected to receive calcium-containing IV solutions.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
