藥物交互作用
Calcium acetate + Ceftriaxone
嚴重程度: 嚴重
Calcium acetate and Ceftriaxone: major interaction.
最後更新
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摘要
Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium in IV lines or in the body. Fatal cases of lung and kidney crystalline deposits have been reported, mainly in neonates. Oral calcium acetate used as a phosphate binder has negligible systemic exposure to this risk, so concern applies mainly to IV calcium.
用白話說明這項交互作用的意義
Calcium acetate and Ceftriaxone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Calcium acetate belongs to Genitourinary; Ceftriaxone belongs to Anti Bacterial.
為什麼會發生
Ceftriaxone binds calcium to form insoluble calcium-ceftriaxone salt that precipitates.
處置方式
Never mix ceftriaxone with calcium-containing IV solutions or give them simultaneously through the same line. In non-neonates, give sequentially with thorough line flushing; in neonates avoid IV calcium during ceftriaxone treatment and for 48 hours after the last dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ceftriaxone 的其他交互作用
Calcium acetate 的其他交互作用
常見問題
Can I take Calcium acetate with Ceftriaxone?
MediHelp rates the interaction as major. Calcium acetate and Ceftriaxone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceftriaxone can form insoluble ceftriaxone-calcium precipitates when mixed with calcium in IV lines or in the body. Fatal cases of lung and kidney crystalline deposits have been reported, mainly in neonates. Oral calcium acetate used as a phosphate binder has negligible systemic exposure to this risk, so concern applies mainly to IV calcium.
How serious is the interaction between Calcium acetate and Ceftriaxone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never mix ceftriaxone with calcium-containing IV solutions or give them simultaneously through the same line. In non-neonates, give sequentially with thorough line flushing; in neonates avoid IV calcium during ceftriaxone treatment and for 48 hours after the last dose.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
