藥物交互作用
Charcoal + Leflunomide
嚴重程度: 中度
Charcoal and Leflunomide: moderate interaction.
最後更新
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摘要
Activated charcoal binds leflunomide's active metabolite teriflunomide and interrupts its enterohepatic recirculation, lowering levels. This effect is used deliberately in leflunomide washout and would reduce therapeutic effect during routine treatment.
用白話說明這項交互作用的意義
Charcoal and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Charcoal belongs to Gastrointestinal Tract; Leflunomide belongs to Musculoskeletal.
為什麼會發生
Charcoal adsorbs the drug in the gut and interrupts enterohepatic recycling of teriflunomide.
處置方式
Avoid routine charcoal use during leflunomide therapy, or separate dosing by several hours. Use charcoal intentionally only for drug elimination.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Charcoal 的其他交互作用
Leflunomide 的其他交互作用
常見問題
Can I take Charcoal with Leflunomide?
MediHelp rates the interaction as moderate. Charcoal and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal binds leflunomide's active metabolite teriflunomide and interrupts its enterohepatic recirculation, lowering levels. This effect is used deliberately in leflunomide washout and would reduce therapeutic effect during routine treatment.
How serious is the interaction between Charcoal and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine charcoal use during leflunomide therapy, or separate dosing by several hours. Use charcoal intentionally only for drug elimination.
What other medicines interact with Charcoal?
MediHelp also lists interactions of Charcoal with, for example, Citalopram, Digoxin, Methotrexate. The full list is on the Charcoal page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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