藥物交互作用
Cholestyramine + Mycophenolate
嚴重程度: 嚴重
Cholestyramine and Mycophenolate: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, which lowers exposure. This can reduce immunosuppression and raise the risk of rejection in transplant patients.
用白話說明這項交互作用的意義
Cholestyramine and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Binding in the gut reduces absorption and enterohepatic recycling of mycophenolic acid.
處置方式
Avoid concurrent use where possible; if cholestyramine is needed, consider alternatives. Monitor graft function and mycophenolic acid exposure if used together.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cholestyramine 的其他交互作用
常見問題
Can I take Cholestyramine with Mycophenolate?
MediHelp rates the interaction as major. Cholestyramine and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, which lowers exposure. This can reduce immunosuppression and raise the risk of rejection in transplant patients.
How serious is the interaction between Cholestyramine and Mycophenolate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if cholestyramine is needed, consider alternatives. Monitor graft function and mycophenolic acid exposure if used together.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
