藥物交互作用
Cholestyramine + Mycophenolate mofetil
嚴重程度: 嚴重
Cholestyramine and Mycophenolate mofetil: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cholestyramine binds mycophenolic acid in the gut and interrupts its enterohepatic circulation, reducing exposure by about 40 percent. Loss of immunosuppression raises the risk of rejection.
用白話說明這項交互作用的意義
Cholestyramine and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Mycophenolate mofetil belongs to Miscellaneous.
為什麼會發生
Bile acid sequestrant binding of mycophenolic acid and its glucuronide interrupts enterohepatic recirculation
處置方式
Avoid combining; if cholestyramine is unavoidable give it well apart from mycophenolate and monitor graft function and mycophenolate exposure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Mycophenolate mofetil 的其他交互作用
- Adenovirus types 4 and 7 live + Mycophenolate mofetil 禁忌併用
- Bcg vaccine live + Mycophenolate mofetil 禁忌併用
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil 禁忌併用
- Measles mumps and rubella vaccine live + Mycophenolate mofetil 禁忌併用
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil 禁忌併用
- Measles vaccine + Mycophenolate mofetil 禁忌併用
Cholestyramine 的其他交互作用
常見問題
Can I take Cholestyramine with Mycophenolate mofetil?
MediHelp rates the interaction as major. Cholestyramine and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds mycophenolic acid in the gut and interrupts its enterohepatic circulation, reducing exposure by about 40 percent. Loss of immunosuppression raises the risk of rejection.
How serious is the interaction between Cholestyramine and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; if cholestyramine is unavoidable give it well apart from mycophenolate and monitor graft function and mycophenolate exposure.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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