藥物交互作用
Cholestyramine + Levothyroxine
嚴重程度: 嚴重
Cholestyramine and Levothyroxine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cholestyramine markedly reduces levothyroxine absorption, which can cause hypothyroidism or loss of TSH suppression in treated patients.
用白話說明這項交互作用的意義
Cholestyramine and Levothyroxine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Levothyroxine belongs to Endocrine.
為什麼會發生
Resin binds levothyroxine in the gut and prevents its absorption.
處置方式
Separate levothyroxine from cholestyramine by at least 4 hours. Check TSH after starting or stopping the resin and adjust the dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cholestyramine 的其他交互作用
Levothyroxine 的其他交互作用
常見問題
Can I take Cholestyramine with Levothyroxine?
MediHelp rates the interaction as major. Cholestyramine and Levothyroxine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine markedly reduces levothyroxine absorption, which can cause hypothyroidism or loss of TSH suppression in treated patients.
How serious is the interaction between Cholestyramine and Levothyroxine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate levothyroxine from cholestyramine by at least 4 hours. Check TSH after starting or stopping the resin and adjust the dose.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
