藥物交互作用
Cilastatin-imipenem + Microbiota
嚴重程度: 中度
Cilastatin-imipenem and Microbiota: moderate interaction.
最後更新
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摘要
Oral microbiota spore products require live bacteria to colonize the gut. Imipenem is a broad-spectrum carbapenem that may kill the administered organisms and reduce efficacy. Careful timing after antibiotic therapy is needed.
用白話說明這項交互作用的意義
Cilastatin-imipenem and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Antibacterial activity against the live bacterial content impairs engraftment.
處置方式
Finish antibiotic therapy and observe the labeled washout interval before administering the microbiota product. Avoid concurrent systemic antibiotics where possible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cilastatin-imipenem 的其他交互作用
常見問題
Can I take Cilastatin-imipenem with Microbiota?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota spore products require live bacteria to colonize the gut. Imipenem is a broad-spectrum carbapenem that may kill the administered organisms and reduce efficacy. Careful timing after antibiotic therapy is needed.
How serious is the interaction between Cilastatin-imipenem and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Finish antibiotic therapy and observe the labeled washout interval before administering the microbiota product. Avoid concurrent systemic antibiotics where possible.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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