藥物交互作用
Clomipramine + Cocaine
嚴重程度: 嚴重
Clomipramine and Cocaine: major interaction.
最後更新
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摘要
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and clomipramine has similar actions on serotonin and norepinephrine. The combination can increase sympathomimetic and serotonergic effects, including hypertension, arrhythmias and serotonin toxicity. Topical use at a clinical dose has lower systemic exposure, but significant absorption can occur from mucosal use.
用白話說明這項交互作用的意義
Clomipramine and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Cocaine belongs to Central Nervous System.
為什麼會發生
Additive monoamine reuptake inhibition, with potentiated adrenergic effects and arrhythmia risk.
處置方式
Avoid cocaine, including recreational use, in patients taking clomipramine. If topical cocaine is required, use the minimum dose and monitor blood pressure and ECG.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clomipramine 的其他交互作用
Cocaine 的其他交互作用
常見問題
Can I take Clomipramine with Cocaine?
MediHelp rates the interaction as major. Clomipramine and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and clomipramine has similar actions on serotonin and norepinephrine. The combination can increase sympathomimetic and serotonergic effects, including hypertension, arrhythmias and serotonin toxicity. Topical use at a clinical dose has lower systemic exposure, but significant absorption can occur from mucosal use.
How serious is the interaction between Clomipramine and Cocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including recreational use, in patients taking clomipramine. If topical cocaine is required, use the minimum dose and monitor blood pressure and ECG.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
