藥物交互作用
Cocaine + Procarbazine
嚴重程度: 禁忌併用
Cocaine and Procarbazine: contraindicated interaction.
最後更新
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摘要
Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
用白話說明這項交互作用的意義
Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Procarbazine belongs to Oncology.
為什麼會發生
MAO inhibition increases monoamine stores while cocaine blocks reuptake, producing additive sympathomimetic and serotonergic effects.
處置方式
Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Procarbazine 的其他交互作用
Cocaine 的其他交互作用
常見問題
Can I take Cocaine with Procarbazine?
MediHelp rates the interaction as contraindicated. Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
How serious is the interaction between Cocaine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
