藥物交互作用
Clozapine + Pefloxacin
嚴重程度: 嚴重
Clozapine and Pefloxacin: major interaction.
最後更新
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摘要
Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.
用白話說明這項交互作用的意義
Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
為什麼會發生
Pefloxacin inhibits CYP1A2, decreasing clozapine clearance.
處置方式
Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clozapine 的其他交互作用
Pefloxacin 的其他交互作用
常見問題
Can I take Clozapine with Pefloxacin?
MediHelp rates the interaction as major. Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.
How serious is the interaction between Clozapine and Pefloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
