藥物交互作用
Duloxetine + Pefloxacin
嚴重程度: 嚴重
Duloxetine and Pefloxacin: major interaction.
最後更新
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摘要
Pefloxacin inhibits CYP1A2 and may raise duloxetine concentrations, increasing adverse effects such as nausea, dizziness, blood pressure rise and serotonergic toxicity. Strong CYP1A2 inhibitors such as fluoroquinolones like ciprofloxacin are labeled for avoidance with duloxetine.
用白話說明這項交互作用的意義
Duloxetine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP1A2-mediated duloxetine metabolism by pefloxacin.
處置方式
Prefer an antibiotic that does not inhibit CYP1A2. If unavoidable, monitor for duloxetine adverse effects and consider dose reduction.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Duloxetine 的其他交互作用
Pefloxacin 的其他交互作用
常見問題
Can I take Duloxetine with Pefloxacin?
MediHelp rates the interaction as major. Duloxetine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pefloxacin inhibits CYP1A2 and may raise duloxetine concentrations, increasing adverse effects such as nausea, dizziness, blood pressure rise and serotonergic toxicity. Strong CYP1A2 inhibitors such as fluoroquinolones like ciprofloxacin are labeled for avoidance with duloxetine.
How serious is the interaction between Duloxetine and Pefloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If unavoidable, monitor for duloxetine adverse effects and consider dose reduction.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
