藥物交互作用
Cimetidine + Pefloxacin
嚴重程度: 中度
Cimetidine and Pefloxacin: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.
用白話說明這項交互作用的意義
Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Pefloxacin belongs to Anti Bacterial.
為什麼會發生
Cimetidine inhibits hepatic oxidative metabolism of pefloxacin, reducing its clearance.
處置方式
Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cimetidine 的其他交互作用
Pefloxacin 的其他交互作用
常見問題
Can I take Cimetidine with Pefloxacin?
MediHelp rates the interaction as moderate. Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.
How serious is the interaction between Cimetidine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
