藥物交互作用
Caffeine + Pefloxacin
嚴重程度: 中度
Caffeine and Pefloxacin: moderate interaction.
最後更新
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摘要
Pefloxacin inhibits caffeine metabolism and reduces its clearance, raising caffeine levels and half-life. This may cause jitteriness, insomnia, tachycardia and, at high intake, seizures or arrhythmias.
用白話說明這項交互作用的意義
Caffeine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Pefloxacin belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP1A2-mediated caffeine metabolism by pefloxacin.
處置方式
Advise patients to reduce caffeine intake while taking pefloxacin and watch for tremor, insomnia, palpitations or agitation.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Caffeine 的其他交互作用
Pefloxacin 的其他交互作用
常見問題
Can I take Caffeine with Pefloxacin?
MediHelp rates the interaction as moderate. Caffeine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits caffeine metabolism and reduces its clearance, raising caffeine levels and half-life. This may cause jitteriness, insomnia, tachycardia and, at high intake, seizures or arrhythmias.
How serious is the interaction between Caffeine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to reduce caffeine intake while taking pefloxacin and watch for tremor, insomnia, palpitations or agitation.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
