藥物交互作用
Colesevelam + Cyclosporin
嚴重程度: 中度
Colesevelam and Cyclosporin: moderate interaction.
最後更新
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摘要
Colesevelam can bind cyclosporine in the gut and reduce its absorption, leading to lower blood concentrations and a risk of rejection. Taking cyclosporine well before colesevelam avoids the effect.
用白話說明這項交互作用的意義
Colesevelam and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Cyclosporin belongs to Miscellaneous.
為什麼會發生
Bile acid sequestrant binds cyclosporine in the gastrointestinal tract, reducing absorption.
處置方式
Give cyclosporine at least 4 hours before colesevelam and monitor cyclosporine trough levels.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cyclosporin 的其他交互作用
Colesevelam 的其他交互作用
常見問題
Can I take Colesevelam with Cyclosporin?
MediHelp rates the interaction as moderate. Colesevelam and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind cyclosporine in the gut and reduce its absorption, leading to lower blood concentrations and a risk of rejection. Taking cyclosporine well before colesevelam avoids the effect.
How serious is the interaction between Colesevelam and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cyclosporine at least 4 hours before colesevelam and monitor cyclosporine trough levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
