藥物交互作用
Cholic acid + Colesevelam
嚴重程度: 中度
Cholic acid and Colesevelam: moderate interaction.
最後更新
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摘要
Bile acid sequestrants bind bile acids in the gut and can reduce absorption of cholic acid, weakening its therapeutic effect in bile acid synthesis disorders.
用白話說明這項交互作用的意義
Cholic acid and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Colesevelam belongs to Endocrine.
為什麼會發生
Colesevelam binds cholic acid in the gastrointestinal lumen, reducing absorption.
處置方式
Take cholic acid at least 1 hour before or 4 to 6 hours after colesevelam, and monitor liver biochemistry and clinical response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Colesevelam 的其他交互作用
Cholic acid 的其他交互作用
常見問題
Can I take Cholic acid with Colesevelam?
MediHelp rates the interaction as moderate. Cholic acid and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants bind bile acids in the gut and can reduce absorption of cholic acid, weakening its therapeutic effect in bile acid synthesis disorders.
How serious is the interaction between Cholic acid and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take cholic acid at least 1 hour before or 4 to 6 hours after colesevelam, and monitor liver biochemistry and clinical response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
