藥物交互作用
Conivaptan + Eletriptan
嚴重程度: 禁忌併用
Conivaptan and Eletriptan: contraindicated interaction.
最後更新
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摘要
Conivaptan is a potent CYP3A4 inhibitor and can substantially increase eletriptan exposure. This raises the risk of triptan toxicity, including hypertension and vasospasm. Eletriptan labeling warns against use with potent CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Conivaptan and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Potent inhibition of CYP3A4-mediated eletriptan metabolism.
處置方式
Avoid eletriptan during and for at least 72 hours after conivaptan. Select a triptan that is not a CYP3A4 substrate if needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eletriptan 的其他交互作用
常見問題
Can I take Conivaptan with Eletriptan?
MediHelp rates the interaction as contraindicated. Conivaptan and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a potent CYP3A4 inhibitor and can substantially increase eletriptan exposure. This raises the risk of triptan toxicity, including hypertension and vasospasm. Eletriptan labeling warns against use with potent CYP3A4 inhibitors.
How serious is the interaction between Conivaptan and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during and for at least 72 hours after conivaptan. Select a triptan that is not a CYP3A4 substrate if needed.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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