藥物交互作用
Conivaptan + Irinotecan
嚴重程度: 嚴重
Conivaptan and Irinotecan: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Conivaptan is a CYP3A4 inhibitor and may raise irinotecan and SN-38 exposure. Severe diarrhea and myelosuppression are possible.
用白話說明這項交互作用的意義
Conivaptan and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Conivaptan inhibits CYP3A4, reducing irinotecan oxidative metabolism.
處置方式
Avoid concurrent use where possible, and treat hyponatremia with an alternative. If it must be used, monitor for diarrhea and neutropenia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Irinotecan 的其他交互作用
常見問題
Can I take Conivaptan with Irinotecan?
MediHelp rates the interaction as major. Conivaptan and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conivaptan is a CYP3A4 inhibitor and may raise irinotecan and SN-38 exposure. Severe diarrhea and myelosuppression are possible.
How serious is the interaction between Conivaptan and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, and treat hyponatremia with an alternative. If it must be used, monitor for diarrhea and neutropenia.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
