藥物交互作用
Cyclosporin + Darolutamide
嚴重程度: 中度
Cyclosporin and Darolutamide: moderate interaction.
最後更新
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摘要
Cyclosporine inhibits both P-gp and CYP3A4, and darolutamide is a substrate of both, so darolutamide exposure may increase. This could heighten adverse effects such as fatigue and cardiac or hepatic events.
用白話說明這項交互作用的意義
Cyclosporin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Darolutamide belongs to Miscellaneous.
為什麼會發生
Combined P-gp and CYP3A4 inhibition by cyclosporine increases darolutamide absorption and reduces clearance.
處置方式
Monitor for darolutamide adverse reactions and reduce the dose if they emerge. Consider an alternative immunosuppressant if feasible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cyclosporin 的其他交互作用
Darolutamide 的其他交互作用
常見問題
Can I take Cyclosporin with Darolutamide?
MediHelp rates the interaction as moderate. Cyclosporin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits both P-gp and CYP3A4, and darolutamide is a substrate of both, so darolutamide exposure may increase. This could heighten adverse effects such as fatigue and cardiac or hepatic events.
How serious is the interaction between Cyclosporin and Darolutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darolutamide adverse reactions and reduce the dose if they emerge. Consider an alternative immunosuppressant if feasible.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
