藥物交互作用
Darolutamide + Efavirenz
嚴重程度: 嚴重
Darolutamide and Efavirenz: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Efavirenz may decrease darolutamide exposure because darolutamide is cleared by CYP3A4 and P-gp, which could reduce control of prostate cancer.
用白話說明這項交互作用的意義
Darolutamide and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darolutamide belongs to Miscellaneous; Efavirenz belongs to Anti Virals.
為什麼會發生
Efavirenz induces CYP3A4 and P-gp, lowering darolutamide concentrations.
處置方式
Avoid combined P-gp and CYP3A4 inducers where possible. If it cannot be avoided, monitor PSA and clinical response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Efavirenz 的其他交互作用
Darolutamide 的其他交互作用
常見問題
Can I take Darolutamide with Efavirenz?
MediHelp rates the interaction as major. Darolutamide and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz may decrease darolutamide exposure because darolutamide is cleared by CYP3A4 and P-gp, which could reduce control of prostate cancer.
How serious is the interaction between Darolutamide and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined P-gp and CYP3A4 inducers where possible. If it cannot be avoided, monitor PSA and clinical response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
