藥物交互作用
Carbamazepine + Darolutamide
嚴重程度: 嚴重
Carbamazepine and Darolutamide: major interaction.
最後更新
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摘要
Carbamazepine lowers darolutamide exposure and may reduce its efficacy in prostate cancer.
用白話說明這項交互作用的意義
Carbamazepine and Darolutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Darolutamide belongs to Miscellaneous.
為什麼會發生
Combined P-glycoprotein and CYP3A4 induction increases darolutamide clearance.
處置方式
Avoid coadministration and use a non-inducing anticonvulsant. If unavoidable, monitor PSA and disease progression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbamazepine 的其他交互作用
Darolutamide 的其他交互作用
常見問題
Can I take Carbamazepine with Darolutamide?
MediHelp rates the interaction as major. Carbamazepine and Darolutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine lowers darolutamide exposure and may reduce its efficacy in prostate cancer.
How serious is the interaction between Carbamazepine and Darolutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use a non-inducing anticonvulsant. If unavoidable, monitor PSA and disease progression.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
