藥物交互作用
Darolutamide + Phenobarbitone
嚴重程度: 嚴重
Darolutamide and Phenobarbitone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Phenobarbitone is expected to lower darolutamide exposure and may reduce anticancer efficacy.
用白話說明這項交互作用的意義
Darolutamide and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darolutamide belongs to Miscellaneous; Phenobarbitone belongs to Central Nervous System.
為什麼會發生
Induction of CYP3A4 and P-glycoprotein by phenobarbitone increases darolutamide clearance.
處置方式
Avoid unless there is no alternative; prefer a non-inducing anticonvulsant. If used, monitor PSA and clinical response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Darolutamide 的其他交互作用
Phenobarbitone 的其他交互作用
常見問題
Can I take Darolutamide with Phenobarbitone?
MediHelp rates the interaction as major. Darolutamide and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenobarbitone is expected to lower darolutamide exposure and may reduce anticancer efficacy.
How serious is the interaction between Darolutamide and Phenobarbitone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless there is no alternative; prefer a non-inducing anticonvulsant. If used, monitor PSA and clinical response.
What other medicines interact with Darolutamide?
MediHelp also lists interactions of Darolutamide with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Darolutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
