藥品參考
Darolutamide
Darolutamide is a medicine in the class miscellaneous. It is used for prostate cancer.
- 藥物類別: Miscellaneous
- 用途: prostate cancer
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- 常見劑型
- 錠劑
- 常見規格
- 300 mg
- 已知交互作用
- 43 (嚴重: 7 · 中度: 30 · 輕微: 6)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Androgen receptor inhibitor that binds the receptor ligand binding domain and competitively inhibits androgen binding, AR nuclear translocation and AR-mediated transcription, decreasing prostate tumour cell proliferation.
成人常用劑量（仿單摘要）
nmCRPC and mHSPC: 600 mg (two 300 mg tablets) orally twice daily (total 1200 mg/day), continued until disease progression or unacceptable toxicity; continue medical castration with LHRH analogue if not surgically castrated.
懷孕與哺乳
- 懷孕
- Unsafe Contraindicated in women who are or may become pregnant; may cause foetal harm based on mechanism of action.
- 哺乳
- Unsafe Not to be used in breast-feeding women; excretion in milk unknown and risk to child cannot be excluded.
已通報的副作用
- Fatigue/asthenic conditions
- Rash
- Hypertension
- Neutrophil count decreased
- Blood bilirubin increased
- AST increased
禁忌症
- Hypersensitivity to the active substance or any excipient.
- Women who are or may become pregnant.
哪些人需要特別留意
- Severe renal or moderate/severe hepatic impairment: exposure may be increased; monitor closely for adverse reactions.
- Safety not established in patients with recent clinically significant cardiovascular disease (past 6 months); treat cardiovascular conditions per guidelines.
- Hepatotoxicity: permanently discontinue if liver tests suggest idiosyncratic drug-induced liver injury.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (43)
- Apalutamide + Darolutamide Major
- Carbamazepine + Darolutamide Major
- Darolutamide + Efavirenz Major
- Darolutamide + Phenobarbitone Major
- Darolutamide + Phenytoin Major
- Darolutamide + Rifampicin Major
- Darolutamide + Rosuvastatin Major
- Atorvastatin + Darolutamide Moderate
- Clarithromycin + Darolutamide Moderate
- Cyclosporin + Darolutamide Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Darolutamide 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
相關快速閱讀
常見問題
What is Darolutamide used for?
Darolutamide is a medicine in the class miscellaneous. It is used for Prostate cancer.
What side effects have been reported with Darolutamide?
Fatigue/asthenic conditions, Rash, Hypertension, Neutrophil count decreased, Blood bilirubin increased, AST increased.
Can Darolutamide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in women who are or may become pregnant; may cause foetal harm based on mechanism of action. Breastfeeding: Unsafe. Not to be used in breast-feeding women; excretion in milk unknown and risk to child cannot be excluded.
What does Darolutamide interact with?
MediHelp lists 43 known interactions for Darolutamide. Major: 7 · Moderate: 30 · Minor: 6. The most serious include Apalutamide, Carbamazepine, Efavirenz.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
