藥物交互作用
Dalfampridine + Glyburide-metformin
嚴重程度: 中度
Dalfampridine and Glyburide-metformin: moderate interaction.
最後更新
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摘要
Both metformin and dalfampridine are eliminated through renal tubular secretion by OCT2. Competition could raise exposure of either drug, and higher dalfampridine levels increase seizure risk, particularly in renal impairment.
用白話說明這項交互作用的意義
Dalfampridine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalfampridine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
為什麼會發生
Competition for renal tubular secretion via OCT2 may reduce clearance of both drugs.
處置方式
Check renal function before and during combined use. Watch for seizures or neurologic effects and for metformin adverse effects such as gastrointestinal symptoms.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Glyburide-metformin 的其他交互作用
Dalfampridine 的其他交互作用
常見問題
Can I take Dalfampridine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Dalfampridine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both metformin and dalfampridine are eliminated through renal tubular secretion by OCT2. Competition could raise exposure of either drug, and higher dalfampridine levels increase seizure risk, particularly in renal impairment.
How serious is the interaction between Dalfampridine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before and during combined use. Watch for seizures or neurologic effects and for metformin adverse effects such as gastrointestinal symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
