藥物交互作用
Danazol + Flutamide
嚴重程度: 中度
Danazol and Flutamide: moderate interaction.
最後更新
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摘要
Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
用白話說明這項交互作用的意義
Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Danazol inhibits CYP3A4 and has pharmacodynamic androgenic activity opposing flutamide.
處置方式
Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Flutamide 的其他交互作用
常見問題
Can I take Danazol with Flutamide?
MediHelp rates the interaction as moderate. Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
How serious is the interaction between Danazol and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
