藥物交互作用
Flutamide + Levoketoconazole
嚴重程度: 嚴重
Flutamide and Levoketoconazole: major interaction.
最後更新
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摘要
Levoketoconazole is a strong CYP3A4 inhibitor and may raise flutamide exposure. Both drugs carry a risk of hepatotoxicity, so combined use may increase the chance of liver injury.
用白話說明這項交互作用的意義
Flutamide and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Levoketoconazole belongs to Endocrine.
為什麼會發生
Levoketoconazole strongly inhibits CYP3A4, reducing flutamide metabolism, and both drugs are hepatotoxic.
處置方式
Avoid the combination if possible. If used, monitor liver function tests frequently and stop at signs of liver injury.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Flutamide 的其他交互作用
Levoketoconazole 的其他交互作用
常見問題
Can I take Flutamide with Levoketoconazole?
MediHelp rates the interaction as major. Flutamide and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and may raise flutamide exposure. Both drugs carry a risk of hepatotoxicity, so combined use may increase the chance of liver injury.
How serious is the interaction between Flutamide and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor liver function tests frequently and stop at signs of liver injury.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Pexidartinib, Pretomanid. The full list is on the Flutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
