藥物交互作用
Flutamide + Pretomanid
嚴重程度: 嚴重
Flutamide and Pretomanid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Pretomanid-containing regimens are associated with hepatotoxicity, and flutamide also carries a boxed warning for liver injury. Combined use may increase the chance of serious liver damage.
用白話說明這項交互作用的意義
Flutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
為什麼會發生
Additive hepatotoxicity.
處置方式
Avoid flutamide during pretomanid therapy and use another antiandrogen if needed. If unavoidable, monitor liver enzymes frequently.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Flutamide 的其他交互作用
Pretomanid 的其他交互作用
常見問題
Can I take Flutamide with Pretomanid?
MediHelp rates the interaction as major. Flutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and flutamide also carries a boxed warning for liver injury. Combined use may increase the chance of serious liver damage.
How serious is the interaction between Flutamide and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid flutamide during pretomanid therapy and use another antiandrogen if needed. If unavoidable, monitor liver enzymes frequently.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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