藥物交互作用
Flutamide + Idelalisib
嚴重程度: 嚴重
Flutamide and Idelalisib: major interaction.
最後更新
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摘要
Idelalisib is a strong CYP3A inhibitor and may raise flutamide exposure. Both drugs carry a risk of serious hepatotoxicity, so the combination may increase liver injury risk.
用白話說明這項交互作用的意義
Flutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Idelalisib belongs to Oncology.
為什麼會發生
CYP3A4 inhibition by idelalisib reduces flutamide metabolism, compounded by additive hepatotoxicity.
處置方式
Avoid the combination where possible. If used, monitor liver enzymes frequently and stop either drug if significant elevation occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Flutamide 的其他交互作用
Idelalisib 的其他交互作用
常見問題
Can I take Flutamide with Idelalisib?
MediHelp rates the interaction as major. Flutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and may raise flutamide exposure. Both drugs carry a risk of serious hepatotoxicity, so the combination may increase liver injury risk.
How serious is the interaction between Flutamide and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor liver enzymes frequently and stop either drug if significant elevation occurs.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Levoketoconazole, Pexidartinib, Pretomanid. The full list is on the Flutamide page.
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