藥物交互作用
Deferiprone + Topotecan
嚴重程度: 嚴重
Deferiprone and Topotecan: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Topotecan causes dose-limiting bone marrow suppression, especially neutropenia, and deferiprone can cause agranulocytosis. Combined use may produce severe neutropenia and serious infection.
用白話說明這項交互作用的意義
Deferiprone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Topotecan belongs to Oncology.
為什麼會發生
Additive myelosuppressive toxicity (pharmacodynamic).
處置方式
Avoid if possible; otherwise monitor absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Topotecan 的其他交互作用
Deferiprone 的其他交互作用
常見問題
Can I take Deferiprone with Topotecan?
MediHelp rates the interaction as major. Deferiprone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Topotecan causes dose-limiting bone marrow suppression, especially neutropenia, and deferiprone can cause agranulocytosis. Combined use may produce severe neutropenia and serious infection.
How serious is the interaction between Deferiprone and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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