藥物交互作用
Desloratadine + Erdafitinib
嚴重程度: 中度
Desloratadine and Erdafitinib: moderate interaction.
最後更新
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摘要
Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as desloratadine. Because desloratadine has a wide therapeutic margin, the clinical consequence is usually limited.
用白話說明這項交互作用的意義
Desloratadine and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desloratadine belongs to Respiratory; Erdafitinib belongs to Oncology.
為什麼會發生
Inhibition of intestinal and cellular P-glycoprotein efflux by erdafitinib increases desloratadine absorption.
處置方式
Monitor for antihistamine adverse effects such as drowsiness or palpitations. Separating doses by at least 6 hours is a reasonable measure if concern exists.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Desloratadine 的其他交互作用
Erdafitinib 的其他交互作用
常見問題
Can I take Desloratadine with Erdafitinib?
MediHelp rates the interaction as moderate. Desloratadine and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as desloratadine. Because desloratadine has a wide therapeutic margin, the clinical consequence is usually limited.
How serious is the interaction between Desloratadine and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antihistamine adverse effects such as drowsiness or palpitations. Separating doses by at least 6 hours is a reasonable measure if concern exists.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Isocarboxazid, Tranylcypromine, Zuranolone. The full list is on the Desloratadine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
