藥物交互作用
Dexamethasone + Nivolumab
嚴重程度: 中度
Dexamethasone and Nivolumab: moderate interaction.
最後更新
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摘要
Corticosteroids can blunt the immune activation on which nivolumab depends, though they are also the standard treatment for immune-related adverse events. Use at physiological doses or for managing toxicity is acceptable, whereas high-dose prophylactic or prolonged use may reduce efficacy.
用白話說明這項交互作用的意義
Dexamethasone and Nivolumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Nivolumab belongs to Oncology.
為什麼會發生
Pharmacodynamic antagonism: glucocorticoid immunosuppression opposes T-cell mediated antitumor activity enabled by PD-1 blockade.
處置方式
Avoid unnecessary corticosteroids before or during nivolumab. Use dexamethasone when needed for immune-related adverse events or supportive care at the lowest effective dose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dexamethasone 的其他交互作用
Nivolumab 的其他交互作用
常見問題
Can I take Dexamethasone with Nivolumab?
MediHelp rates the interaction as moderate. Dexamethasone and Nivolumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can blunt the immune activation on which nivolumab depends, though they are also the standard treatment for immune-related adverse events. Use at physiological doses or for managing toxicity is acceptable, whereas high-dose prophylactic or prolonged use may reduce efficacy.
How serious is the interaction between Dexamethasone and Nivolumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary corticosteroids before or during nivolumab. Use dexamethasone when needed for immune-related adverse events or supportive care at the lowest effective dose.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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