藥物交互作用
Efgartigimod alfa + Nivolumab
嚴重程度: 中度
Efgartigimod alfa and Nivolumab: moderate interaction.
最後更新
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摘要
Efgartigimod blocks the neonatal Fc receptor, which normally protects IgG antibodies from degradation. Nivolumab is an IgG4 antibody, so its clearance could increase and exposure fall, potentially weakening antitumor effect. The clinical significance is uncertain.
用白話說明這項交互作用的意義
Efgartigimod alfa and Nivolumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efgartigimod alfa belongs to Miscellaneous; Nivolumab belongs to Oncology.
為什麼會發生
Efgartigimod blocks FcRn-mediated IgG recycling, which may accelerate catabolism of IgG-based nivolumab.
處置方式
Avoid combining where possible, or monitor tumor response closely if efgartigimod is necessary. Consider timing nivolumab doses away from periods of maximal FcRn blockade only with specialist input.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Nivolumab 的其他交互作用
Efgartigimod alfa 的其他交互作用
常見問題
Can I take Efgartigimod alfa with Nivolumab?
MediHelp rates the interaction as moderate. Efgartigimod alfa and Nivolumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which normally protects IgG antibodies from degradation. Nivolumab is an IgG4 antibody, so its clearance could increase and exposure fall, potentially weakening antitumor effect. The clinical significance is uncertain.
How serious is the interaction between Efgartigimod alfa and Nivolumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor tumor response closely if efgartigimod is necessary. Consider timing nivolumab doses away from periods of maximal FcRn blockade only with specialist input.
What other medicines interact with Nivolumab?
MediHelp also lists interactions of Nivolumab with, for example, Thalidomide, Dexamethasone-tobramycin, Dexamethasone. The full list is on the Nivolumab page.
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