藥品參考
Nivolumab
Nivolumab is a medicine in the class oncology. It is used for hodgkin lymphoma.
- 藥物類別: Oncology
- 用途: hodgkin lymphoma
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01FF01
- 常見劑型
- 注射劑
- 常見規格
- 10 mg/ml, 40 mg/4 ml, 100 mg/10 ml
- 已知交互作用
- 13 (嚴重: 1 · 中度: 7 · 輕微: 5)
- 商品名
- 7
- 國家與市場
- 5
用途
作用方式
Monoclonal antibody to programmed cell death-1 protein (PD-1); blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2
成人常用劑量（仿單摘要）
Adjuvant Treatment of Melanoma: 240 mg IV q2Weeks or 480 mg IV q4Weeks
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: blocking PD-1 can break immune tolerance of the fetus; in monkeys it increased abortion and premature infant death. It crosses the placenta, mostly in the 2nd and 3rd trimesters. Check pregnancy status; use effective contraception during and for 5 months after.
- 哺乳
- Unsafe In one mother, milk levels were unexpectedly high and rose with repeated doses (an IgG4 antibody), though infant absorption is probably low. LactMed: avoid while breastfeeding. US label: do not breastfeed during treatment and for 5 months after the last dose.
已通報的副作用
- Rash
- Pruritus
- Cough
- Increased AST
- Hyponatremia
- Increased alkaline phosphatase
哪些人需要特別留意
- In combination with cabozantinib can cause hepatic toxicity with higher frequencies of Grades 3 and 4 ALT and AST elevations compared to drug alone
- Immune-mediated adverse reactions, which may be severe or fatal, can occur in any organ system or tissue, including immune-mediated pneumonitis
- May cause immune-mediated rash, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN);
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (13)
- Nivolumab + Thalidomide Major
- Dexamethasone + Nivolumab Moderate
- Dexamethasone-tobramycin + Nivolumab Moderate
- Efgartigimod / hyaluronidase sc + Nivolumab Moderate
- Efgartigimod alfa + Nivolumab Moderate
- Nivolumab + Ponesimod Moderate
- Nivolumab + Rozanolixizumab Moderate
- Nivolumab + Siponimod Moderate
- Amoxicillin-clavulanic acid + Nivolumab Minor
- Cefalexin + Nivolumab Minor
同類別的其他藥品
常見問題
What is Nivolumab used for?
Nivolumab is a medicine in the class oncology. It is used for Hodgkin lymphoma, Lung cancer, Melanoma, Mesothelioma, Renal cell carcinoma.
What side effects have been reported with Nivolumab?
Rash, Pruritus, Cough, Increased AST, Hyponatremia, Increased alkaline phosphatase.
Can Nivolumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: blocking PD-1 can break immune tolerance of the fetus; in monkeys it increased abortion and premature infant death. It crosses the placenta, mostly in the 2nd and 3rd trimesters. Check pregnancy status; use effective contraception during and for 5 months after. Breastfeeding: Unsafe. In one mother, milk levels were unexpectedly high and rose with repeated doses (an IgG4 antibody), though infant absorption is probably low. LactMed: avoid while breastfeeding. US label: do not breastfeed during treatment and for 5 months after the last dose.
What does Nivolumab interact with?
MediHelp lists 13 known interactions for Nivolumab. Major: 1 · Moderate: 7 · Minor: 5. The most serious include Thalidomide, Dexamethasone, Dexamethasone-tobramycin.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
