藥物交互作用
Dexamethasone-neomycin-polymyxin + Levofloxacin
嚴重程度: 嚴重
Dexamethasone-neomycin-polymyxin and Levofloxacin: major interaction.
最後更新
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摘要
Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
用白話說明這項交互作用的意義
Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Levofloxacin belongs to Anti Bacterial.
為什麼會發生
Additive tendon toxicity from fluoroquinolone effects on tenocytes and corticosteroid-impaired collagen turnover.
處置方式
Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-neomycin-polymyxin 的其他交互作用
- Dexamethasone-neomycin-polymyxin + Ketorolac 嚴重
- Dexamethasone-neomycin-polymyxin + Lapatinib 嚴重
- Dexamethasone-neomycin-polymyxin + Mifepristone 嚴重
- Dexamethasone-neomycin-polymyxin + Moxifloxacin 嚴重
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中度
Levofloxacin 的其他交互作用
常見問題
Can I take Dexamethasone-neomycin-polymyxin with Levofloxacin?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
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