藥物交互作用
Dexamethasone-neomycin-polymyxin + Lapatinib
嚴重程度: 嚴重
Dexamethasone-neomycin-polymyxin and Lapatinib: major interaction.
最後更新
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摘要
Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
用白話說明這項交互作用的意義
Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lapatinib belongs to Oncology.
為什麼會發生
Dexamethasone induces CYP3A4 and increases lapatinib clearance, while lapatinib weakly inhibits CYP3A4 and P-glycoprotein.
處置方式
Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-neomycin-polymyxin 的其他交互作用
- Dexamethasone-neomycin-polymyxin + Ketorolac 嚴重
- Dexamethasone-neomycin-polymyxin + Levofloxacin 嚴重
- Dexamethasone-neomycin-polymyxin + Mifepristone 嚴重
- Dexamethasone-neomycin-polymyxin + Moxifloxacin 嚴重
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中度
Lapatinib 的其他交互作用
常見問題
Can I take Dexamethasone-neomycin-polymyxin with Lapatinib?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
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