藥物交互作用
Dexamethasone-neomycin-polymyxin + Mifepristone
嚴重程度: 嚴重
Dexamethasone-neomycin-polymyxin and Mifepristone: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
用白話說明這項交互作用的意義
Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
為什麼會發生
Glucocorticoid receptor antagonism by mifepristone plus CYP3A4 inhibition of dexamethasone metabolism.
處置方式
With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-neomycin-polymyxin 的其他交互作用
- Dexamethasone-neomycin-polymyxin + Ketorolac 嚴重
- Dexamethasone-neomycin-polymyxin + Lapatinib 嚴重
- Dexamethasone-neomycin-polymyxin + Levofloxacin 嚴重
- Dexamethasone-neomycin-polymyxin + Moxifloxacin 嚴重
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中度
Mifepristone 的其他交互作用
常見問題
Can I take Dexamethasone-neomycin-polymyxin with Mifepristone?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
