藥物交互作用
Dexamethasone-neomycin-polymyxin + Moxifloxacin
嚴重程度: 嚴重
Dexamethasone-neomycin-polymyxin and Moxifloxacin: major interaction.
最後更新
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摘要
Fluoroquinolones given with systemic corticosteroids increase the risk of tendinitis and tendon rupture. Older age and long treatment raise the risk further.
用白話說明這項交互作用的意義
Dexamethasone-neomycin-polymyxin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Moxifloxacin belongs to Anti Bacterial.
為什麼會發生
Additive tendon toxicity from fluoroquinolone effects on tenocytes and corticosteroid impairment of collagen synthesis.
處置方式
Avoid the combination in older patients where an alternative antibiotic exists. Discontinue moxifloxacin at the first sign of tendon pain.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-neomycin-polymyxin 的其他交互作用
- Dexamethasone-neomycin-polymyxin + Ketorolac 嚴重
- Dexamethasone-neomycin-polymyxin + Lapatinib 嚴重
- Dexamethasone-neomycin-polymyxin + Levofloxacin 嚴重
- Dexamethasone-neomycin-polymyxin + Mifepristone 嚴重
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中度
Moxifloxacin 的其他交互作用
常見問題
Can I take Dexamethasone-neomycin-polymyxin with Moxifloxacin?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones given with systemic corticosteroids increase the risk of tendinitis and tendon rupture. Older age and long treatment raise the risk further.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where an alternative antibiotic exists. Discontinue moxifloxacin at the first sign of tendon pain.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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