藥物交互作用
Dexamethasone-neomycin-polymyxin + Ketorolac
嚴重程度: 嚴重
Dexamethasone-neomycin-polymyxin and Ketorolac: major interaction.
最後更新
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摘要
Ketorolac carries a high intrinsic risk of GI ulceration and bleeding, and corticosteroids add to this risk. The combination is of concern with systemic exposure to dexamethasone.
用白話說明這項交互作用的意義
Dexamethasone-neomycin-polymyxin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Ketorolac belongs to Musculoskeletal.
為什麼會發生
Additive gastrointestinal mucosal injury from corticosteroids and potent NSAID prostaglandin inhibition.
處置方式
Keep ketorolac to the shortest course allowed by labeling and consider gastroprotection with a proton pump inhibitor. Avoid in patients with prior ulcer or GI bleed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-neomycin-polymyxin 的其他交互作用
- Dexamethasone-neomycin-polymyxin + Lapatinib 嚴重
- Dexamethasone-neomycin-polymyxin + Levofloxacin 嚴重
- Dexamethasone-neomycin-polymyxin + Mifepristone 嚴重
- Dexamethasone-neomycin-polymyxin + Moxifloxacin 嚴重
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中度
Ketorolac 的其他交互作用
常見問題
Can I take Dexamethasone-neomycin-polymyxin with Ketorolac?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac carries a high intrinsic risk of GI ulceration and bleeding, and corticosteroids add to this risk. The combination is of concern with systemic exposure to dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac to the shortest course allowed by labeling and consider gastroprotection with a proton pump inhibitor. Avoid in patients with prior ulcer or GI bleed.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Lapatinib, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
