藥物交互作用
Diflunisal + Prasugrel
嚴重程度: 嚴重
Diflunisal and Prasugrel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.
用白話說明這項交互作用的意義
Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
為什麼會發生
Additive platelet inhibition (P2Y12 blockade plus COX-1 inhibition) and NSAID gastric mucosal injury.
處置方式
Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Diflunisal 的其他交互作用
Prasugrel 的其他交互作用
常見問題
Can I take Diflunisal with Prasugrel?
MediHelp rates the interaction as major. Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.
How serious is the interaction between Diflunisal and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
