藥物交互作用
Cangrelor + Prasugrel
嚴重程度: 嚴重
Cangrelor and Prasugrel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cangrelor reversibly blocks the platelet P2Y12 receptor and can prevent the active metabolite of prasugrel from binding if given during the infusion. This results in loss of the intended antiplatelet effect of prasugrel and a risk of stent thrombosis.
用白話說明這項交互作用的意義
Cangrelor and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cangrelor belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.
為什麼會發生
Competition at the P2Y12 receptor, where cangrelor occupies the binding site and blocks the irreversible binding of prasugrel's active metabolite.
處置方式
Give prasugrel only after the cangrelor infusion has been discontinued, not during it.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cangrelor 的其他交互作用
Prasugrel 的其他交互作用
常見問題
Can I take Cangrelor with Prasugrel?
MediHelp rates the interaction as major. Cangrelor and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cangrelor reversibly blocks the platelet P2Y12 receptor and can prevent the active metabolite of prasugrel from binding if given during the infusion. This results in loss of the intended antiplatelet effect of prasugrel and a risk of stent thrombosis.
How serious is the interaction between Cangrelor and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give prasugrel only after the cangrelor infusion has been discontinued, not during it.
What other medicines interact with Cangrelor?
MediHelp also lists interactions of Cangrelor with, for example, Clopidogrel, Warfarin. The full list is on the Cangrelor page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
