藥物交互作用
Dihydroergotamine intranasal + Rizatriptan
嚴重程度: 禁忌併用
Dihydroergotamine intranasal and Rizatriptan: contraindicated interaction.
最後更新
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摘要
Systemically absorbed intranasal dihydroergotamine adds vasoconstrictor effect to rizatriptan, risking prolonged vasospasm and ischemic events.
用白話說明這項交互作用的意義
Dihydroergotamine intranasal and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects.
處置方式
Do not combine; separate by at least 24 hours. Choose one therapy for each attack.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Rizatriptan 的其他交互作用
常見問題
Can I take Dihydroergotamine intranasal with Rizatriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Systemically absorbed intranasal dihydroergotamine adds vasoconstrictor effect to rizatriptan, risking prolonged vasospasm and ischemic events.
How serious is the interaction between Dihydroergotamine intranasal and Rizatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; separate by at least 24 hours. Choose one therapy for each attack.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine, Eletriptan. The full list is on the Rizatriptan page.
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